| No. | Code | Name | CLASS-LEVEL ANNOTATION | CLASS-LEVEL ASSERTION |
|---|
| new class-level annotation | changes to class-level annotation from previous version (2009-09-28) | new class-level assertion | changes to class-level assertion from previous version (2009-09-28) |
| 51 | NPO_290 | REAGENT | | changed preferred name REAGENT IN CHEMICAL CONJUGATION to REAGENT; changed definition | has_role (REAGENT ROLE and (is_realized_in CHEMICAL REACTION)) | changed its parent class from MOLECULE ROLE IN CHEMICAL CONJUGATION to COMPOUND OR MOLECULE. [Reason for change: REAGENT IN CHEMICAL CONJUGATION is not a role but an independent continuant, which can be asserted as a defined class]. |
| 52 | NPO_292 | REAGENT ROLE | added dBXrefID "obo:OBI 0000086" | changed preferred name MOLECULE ROLE IN CHEMICAL CONJUGATION to REAGENT ROLE; changed definition. [Reason for change: to use this class only for specifying the role_of reagents]. | | |
| 53 | NPO_485 | SPACER | | removed "role_of" from definition [Reason for change: SPACER is not a role but an independent continuant, which can be asserted as a defined class]. | | changed parent class from MOLECULAR ROLE to COMPOUND OR MOLECULE; |
| 54 | NPO_599 | LABELING ROLE | | changed preferred name MOLECULE ROLE IN DIAGNOSTIC IMAGING to LABELING ROLE; modified definition | | |
| 55 | NPO_542 | TARGETING ROLE | | changed preferred name MOLECULAR TARGETING ROLE to TARGETING ROLE; modified definition | role_of some TARGETING AGENT | |
| 56 | NPO_830 | TARGET ROLE | | changed preferred name TARGET MOLECULE to TARGET ROLE; modified definition | role_of some TARGET | |
| 57 | NPO_1492 | FUNCTIONALIZING ROLE | | changed preferred name FUNCTIONALIZING AGENT to FUNCTIONALIZING ROLE; modified definition | | |
| 58 | NPO_1414 | EMULSIFIER | added synonym: emulsifying agent | | has_role EMULSIFYING ROLE; agent_in EMULSIFICATION | changed parent class from ROLE to COMPOUND OR MOLECULE |
| 59 | NPO_938 | BIOCOMPATIBLE | | modified definition | | changed parent class from QUALITY OF CONTINUANT to REALIZABLE ENTITY [Reason for change: it is a property realized during interaction with biological systems] |
| 60 | NPO_882 | BIOPOLYMER | | | has_property some BIOCOMPATIBLE | removed "has_quality some BIOCOMPATIBLE" |
| 61 | NPO_1556 | POLY LACTIC-CO-GLYCOLIC ACID | | | has_property some BIOCOMPATIBLE; has_property some BIODEGRADABLE | removed "has_quality some BIOCOMPATIBLE" |
| 62 | NPO_191 | BIODEGRADABLE | | | | changed parent class from QUALITY OF CONTINUANT to DISPOSITION [Reason for change: it is a property realized during interaction with living organisms] |
| 63 | NPO_836 | BIODEGRADABLE NANOPARTICLE | | | has_property some BIODEGRADABLE | removed "has_quality some BIODEGRADABLE" |
| 64 | NPO_421 | ELECTRONEGATIVITY | | modified definition | | changed parent class from QUALITY OF CONTINUANT to REALIZABLE ENTITY [Reason for change: it is a property realized during chemical interactions] |
| 65 | NPO_490 | IMMUNOGENIC | | modified definition | | changed parent class from QUALITY OF CONTINUANT to REALIZABLE ENTITY [Reason for change: it is a property realized during interaction with the immune system] |
| 66 | NPO_628 | IONIZABILITY | | modified definition | | changed parent class from QUALITY OF CONTINUANT to REALIZABLE ENTITY [Reason for change: it is a property realized during chemical interactions] |
| 67 | NPO_428 | IONIZABLE | | modified definiition | | |
| 68 | | | | | | |
| 69 | NPO_638 | SENSITIVITY TO STIMULUS | | replaced "quality" with "disposition" in definition. [Similar change applied to all subclasses of SENSITIVITY OF STIMULUS] | | changed parent class from QUALITY OF CONTINUANT to DISPOSITION [Reason for change: it is a property realized as a response to a stimulus] |
| 70 | NPO_918 | ACOUSTIC IMAGING CONTRAST AGENT | | | has_property some ACOUSTIC SENSITIVE | removed "has_quality some ACOUSTIC SENSITIVE" |
| 71 | NPO_596 | PHOTOSENSITIZING AGENT | | | has properrty some PHOTOSENSITIVE | removed "has_quality some PHOTOSENSITIVE" |
| 72 | NPO_963 | PH-SENSITIVE LINKER | | | has_property some PH-SENSITIVE | removed "has_quality some PH-SENSITIVE" |
| 73 | NPO_1538 | PH-SENSITIVE POLYMERIC NANOPARTICLE | | | has_property some PH-SENSITIVE | removed "has_quality some PH-SENSITIVE" |
| 74 | NPO_1342 | VIABILITY | | modified definition | | changed parent class from QUALITY OF CONTINUANT to REALIZABLE ENTITY [Reason for change: it is a realizable property] |
| 75 | NPO_1343 | CELL VIABILITY | | modified definition | | |
| 76 | NPO_1338 | TOXICITY | | replaced "quality" with "realizable entity" in definition | | changed parent class from QUALITY OF CONTINUANT to REALIZABLE ENTITY [Reason for change: it is a realizable property] |
| 77 | NPO_1341 | DRUG TOXICITY | | | inheres_in some ANTICANCER DRUG | removed "quality_of some ANTICANCER DRUG" |
| 78 | NPO_1340 | CYTOXICITY | | replaced "quality" with "property" in definition | | |
| 79 | NPO_607 | DEPENDENT CONTINUANT | | corrected definition based on BFO | | |
| 80 | NPO_118 | INDEPENDENT CONTINUANT | | corrected definition based on BFO | | |
| 81 | | All BFO classes | added dBXrefID | corrected definition based on BFO, wherever necessary | | |
| 82 | NPO_1367 | COAT | | inserted "material fiat part which is a" in the definition | | changed partent class from MATERIAL BOUNDARY to MATERIAL FIAT PART [reason for change: coat has a thicknes, and therefore it is not 2-dimensional to be a kind of surface] |
| 83 | NPO_489 | SOLUBILITY | | modified definition [reason for change: for clarity] | | changed parent class from PHYSICAL PROPERTY to REALIZABLE ENTITY [reason for change: it is realizable entity - a kind of ability / capability and not a quality. |
| 84 | NPO_500 | WATER SOLUBILITY | | changed preferred name from WATER SOLUBILITY to SOLUBILITY IN WATER [reason for change: for clarity]; modified definition | | |
| 85 | NPO_598 | INSOLUBLE IN WATER | | modified definition [reason for change: for clarity] | | |
| 86 | NPO_514 | SOLUBLE IN WATER | | modified definition [reason for change: for clarity]; removed dBXrefID | | |
| 87 | NPO_204 | HYDROPHILIC | | modified definition [reason for change: for clarity] | | changed parent class from SOLUBLE IN WATER to REALIZABLE ENTITY [reason for change: In the NPO, "hydrophilic" is property of a single molecule in relation to one or more water molecules; "soluble in water" is a property of a solid, liquid or gaseous substance - it is not attributed to a single molecule. |
| 88 | NPO_399 | HYDROPHOBIC | | modified definition [reason for change: for clarity] | | changed parent class from INSOLUBLE IN WATER to REALIZABLE ENTITY [reason for change: In the NPO, "hydrophobic" is property of a single molecule in relation to one or more water molecules; "insoluble in water" is a property of a solid, liquid or gaseous substance - it is not attributed to a single molecule. |
| 89 | NPO_114 | LIPOPHILIC | | modified definition [reason for change: due to change in the definition of the parent class HYDROPHOBIC; for clarity] | | |
| 90 | NPO_732 | AMPHIPHILIC | | modified definition [reason for change: for clarity] | | changed parent class from QUALITY OF CONTINUANT to REALIZABLE ENTITY [reason for change: amphiphilic is a realizable property - a kind of tendency and not a quality. |
| 91 | NPO_1152 | PHYSICAL PROPERTY | | changed preferred name from PHYSICAL PROPERTY to PHYSICAL QUALITY [reason for change: definition of physical property is not exactly the same as physical quality]; removed synonym | | |
| 92 | NPO_763 | WATER-DISPERSIBLE | | modified definition | | changed parent class from QUALITY OF CONTINUANT to REALIZABLE ENTITY [reason for change: water-dispersible is a realizable property - a kind of ability manifested under specific conditions of the solution.] |
| 93 | NPO_1336 | encapsulation efficiency | | modified definition [reason for change: for clarity] | | |
| 94 | NPO_1285 | LENGTH OF TIME | | changed preferred name from TIME to LENGTH OF TIME ; modified definition; removed dBXrefID [reason for change: time is not a quality; length of time is some measure of time associated with the occurrence of an event.] | | changed parent class from PHYSICAL QUALITY to QUALITY OF OCCURRENT[reason for change: directly related to occurrence of events] |
| 95 | NPO_1590 | LONG CIRCULATING HALF LIFE | | modified definition [reason for change: for clarity] | | |
| 96 | NPO_1286 | AGE | | replaced "time" with "length of time" in definition [reason for change: parent class name changed from "time" to "length of time"] | | |
| 97 | NPO_1280 | HALF LIFE | | replaced "time" with "length of time" in definition [reason for change: parent class name changed from "time" to "length of time"] | | |
| 98 | NPO_1528 | TMAX | | replaced "time" with "length of time" in definition [reason for change: parent class name changed from "time" to "length of time"] | | |
| 99 | NPO_1330 | FREQUENCY | | modified definition | | changed parent class from PHYSICAL QUALITY to QUALITY OF OCCURRENT [reason for change: frequency is a type of rate] |
| 100 | NPO_1157 | MAGNETISM | | modified definition | | changed parent class from PHYSICAL QUALITY to REALIZABLE ENTITY [reason for change: magnetism is a type of ability inhering in a material entities to attract or repel nearby material entities.] |