| No. | Code | Name | CLASS-LEVEL ANNOTATION | CLASS-LEVEL ASSERTION |
|---|
| new class-level annotation | changes to class-level annotation from previous version (2009-09-28) | new class-level assertion | changes to class-level assertion from previous version (2009-09-28) |
| 101 | NPO_1364 | SURFACE PROPERTY | | | inheres_in some MATERIAL BOUNDARY [reason for change: to be more specific] | changed parent class from QUALITY OF CONTINUANT to SPECIFICALLY DEPENDENT CONTINUANT |
| 102 | NPO_1314 | MOBILITY | | modified definition | | changed parent class from MOVEMENT QUALITY to REALIZABLE ENTITY [reason for change: it is a type of ability inhering ina material entity that can move or be moved freely] |
| 103 | NPO_1315 | ELECTROPHORETIC MOBILITY | | modified definition [reason for change: for clarity] | | |
| 104 | NPO_1521 | PHARMACOKINETIC PROPERTY | | | | changed parent class from QUALITY OF CONTINUANT to SPECIFICALLY DEPENDENT CONTINUANT [reason for change: it includes both realizable and non-realizable properties] |
| 105 | NPO_672 | MATERIAL ENTITY | | removed synonym "object" [reason for change: to avoid conflict with bfo:object] | | |
| 106 | NPO_1500 | SUBSTANCE | | modified definition [reason for change: for clarity] | | |
| 107 | NPO_1355 | CHARACTERIZATION | | modified definition and its subclasses [reason for change: for clarity] | | changed parent class from PROCESS to EXPERIMENT [reason for change: to be more specific] |
| 108 | NPO_707 | NANOPARTICLE | | modified definition [reason for change: for clarity] | | |
| 109 | NPO_868 | NANOPARTICLE FORMULATION | | modified definition [reason for change: for clarity] | | |
| 110 | NPO_785 | GAS | | removed synonym "gaseous state"[reason for change: gaseous state is not an independent continuant] | | |
| 111 | NPO_1298 | KILOVOLT | added definition | | | |
| 112 | NPO_1272 | KILOGRAM PER LITER | added dBXrefID | | | |
| 113 | NPO_1165 | TESLA | added dBXrefID | | | |
| 114 | NPO_406 | MAGNETIC | added dBXrefID | | | |
| 115 | NPO_1308 | RATE | added dBXrefID | | | |
| 116 | NPO_1382 | RADIOACTIVITY | | changed preferred name from "radioactive property" to "radioactivity"; modified definition | | changed parent class from RADIATION QUALITY to EMISSION |
| 117 | NPO_641 | MATERIAL SITE | | modified definition: [reason for change: to align with BFO snap:Site] | | |
| 118 | NPO_355 | MOLECULAR ENTITY | | | has_quality some MOLECULAR STRUCTURE | changed parent class from MOLECULAR STRUCTURE to MATERIAL ENTITY [reason for change: molecular structure is something that is borne by a molecular entity; therefore, it is not an independent continuant] |
| 119 | NPO_392 | MOLECULAR STRUCTURE | | | quality_of some MOLECULAR ENTITY | changed parent class from MATERIAL ENTITY to QUALITY OF CONTINUANT [reason for change: molecular structure is something that is borne by a molecular entity; therefore, it is not an independent continuant] |
| 120 | NPO_337 | SUPRAMOLECULAR ENTITY | | changed preferred name from SUPRAMOLECULAR STRUCTURE to SUPRAMOLECULAR ENTITY [reason for change: change in parent class]; modified definition | | changed parent class from MOLECULAR STRUCTURE to MOLECULAR ENTITY [reason for change: molecular structure is something that is borne by a molecular entity; therefore, it is not an independent continuant] |
| 121 | NPO_180 | FIAT DENDRIMER PART | | changed preferred name from MOLECULAR COMPONENT IN DENDRIMER to FIAT DENDRIMER PART [reason for change: for clarity]; modified definition | | changed parent class from CHEMICAL COMPONENT to FIAT MATERIAL PART [reason for change: it is a fiat part] |
| 122 | NPO_195 | LINKAGE | | | bearer_of only CHEMICAL INTERACTION | changed parent class from FIAT PROCESS PART to FIAT MATERIAL PART [reason for change: there are no temporal parts in LINKAGE]; deleted has_part only CHEMICAL INTERACTION |
| 123 | NPO_119 | CHEMICAL INTERACTION | | | | changed parent class from FIAT PROCESS PART to SPECIFICALLY DEPENDENT CONTINUANT [reason for change: there is no temporal parts, and it is a type of force] |
| 124 | NPO_922 | CROSSLINKING REAGENT | | | | removed "has_application some COVALENT LINKAGE" |
| 125 | NPO_1146 | SALT | | | | removed "participates_in IONIC BONDING" |
| 126 | NPO_485 | SPACER | | | | removed "has |
| 127 | NPO_1404 | NANOPARTICLE SAMPLE | | | part_of some NANOPARTICLE FORMULATION | changed parent class from NANOPARTICLE FORMULATION to SAMPLE [reason for change: nanoparticle sample is a fiat part_of a nanoparticle formulation] |
| 128 | NPO_760 | SHELL | | modified definition | | changed parent class from MATERIAL SITE to FIAT MATERIAL PART [reaason for change: shell by definition has not space in which other materials can be placed in; it is a fiat material part] |
| 129 | NPO_363 | CORE SITE | | changed preferred name from CORE to CORE SITE [reason for change: for clarity]; modified definition | part_of some CORE PART | |
| 130 | NPO_1497 | CHEMICAL COMPONENT | | | | changed parent class from MATERIAL ENTITY to FIAT MATERIAL PART [reaason for change: it is a cognitive view of differentiating the different parts of a material entity that are chemical in nature.] |
| 131 | NPO_1493 | FUNCTIONALIZING AGENT | | | | changed parent class from MOLECULAR ENTITY to CHEMICAL COMPONENT IN NANOPARTICLE FORMULATION [reaason for change: it is a cognitive view of differentiating parts of a nanoparticle formulation which play functionalizing roles] |
| 132 | NPO_635 | PAYLOAD AGENT ROLE | | changed preferred name from NANOPARTICLE PAYLOAD AGENT to PAYLOAD AGENT ROLE; modified definition | | |
| 133 | NPO_1534 | IMAGING PAYLOAD AGENT | | | has_role PAYLOAD AGENT ROLE | changed parent class from NANOPARTICLE PAYLOAD AGENT to CHEMICAL COMPONENT IN NANOPARTICLE FORMULATION [reaason for change: it is a cognitive view of differentiating parts of a nanoparticle formulation which has an imaging function and play the role of being a payload carried by a nanoparticle] |
| 134 | NPO_206 | COMPONENT ROLE IN NANOPARTICLE | | changed preferred name from MOLECULE ROLE IN NANOPARTICLE to COMPONENT ROLE IN NANOPARTICLE; modified definition | | |
| 135 | NPO_685 | TARGETING AGENT | | modified definition | | |
| 136 | NPO_827 | SURFACE MODIFYING AGENT | | modified definition [reason for change: for clarity; change in parent class] | | changed parent class from NANOPARTICLE SURFACE AGENT to CHEMICAL COMPONENT IN NANOPARTICLE FORMULATION [reaason for change: it is a cognitive view of differentiating parts of a nanoparticle formulation which has surface modifying roles in a nanoparticle formulation] |
| 137 | NPO_127 | NANOPARTICLE SURFACE MODIFYING ROLE | | changed preferred name from NANOPARTICLE SURFACE AGENT to NANOPARTICLE SURFACE MODIFYING ROLE; modified definition; removed all synonyms [reason for change: to represent this class as the role that inheres in a nanoparticle surface modifying agent] | | |
| 138 | NPO_1383 | RADIOACTIVE | | | | changed parent class from RADIOACTIVITY to DISPOSITION [ |
| 139 | NPO_1376 | FLUORESCENT | | created synonym FLUORESCENCE PROPERTY; modified definition | | changed parent class from OPTICAL QUALITY to DISPOSITION |
| 140 | NPO_312 | ANTICANCER DRUG | | | has_role ANTICANCER DRUG ROLE; has_property PHARMACOKINETIC PROPERTY; has_function THERAPEUTIC FUNCTION | changed parent class from CANCER THERAPEUTIC ROLE OF MOLECULE to COMPOUND OR MOLECULE; removed has_quality PHARMACOKINETIC PROPERTY |
| 141 | NPO_281 | ANTICANCER DRUG ROLE | | changed preferred name ANTICANCER THERAPEUTIC ROLE OF MOLECULE to ANTICANCER DRUG ROLE | | |
| 142 | NPO_576 | INHIBITOR ROLE | | changed preferred name from THERAPEUTIC ROLE OF MOLECULE to INHIBITOR ROLE; modified definition | is_realized_in INHIBITION | |
| 143 | NPO_595 | ANGIOGENESIS INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in ANGIOGENESIS INHIBITION); has_function (THERAPEUTIC FUNCTION and is_realized_in ANGIOGENESIS INHIBITION) | removed inhibits ANGIOGENESIS |
| 144 | NPO_254 | TAMOXIFEN | | | has_function (BINDING FUNCTION and realized_as ESTROGEN RECEPTOR BINDING); has_function (THERAPEUTIC FUNCTION and is_realized_in ANTINEOPLASTIC ACTIVITY); has_role ANTICANCER DRUG ROLE | removed has_role SELECTIVE ESTROGEN RECEPTOR MODULATOR |
| 145 | NPO_777 | ANTINEOPLASTIC AGENT | | | has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role INHIBITOR ROLE | |
| 146 | NPO_839 | BLEOMYCIN | | | has_function (THERAPEUTIC FUNCTION and realized_as_process ANTINEOPLASTIC ACTIVITY); has_role ANTICANCER DRUG ROLE; has_function THERAPEUTIC FUNCTION and (is_realized_in ANGIOGENESIS INHIBITION); has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH); has_function (ALKYLATING FUNCTION and (is_realized_in DNA ALKYLATION)); has_function (BINDING FUNCTION and (is_realized_in DNA BINDING)); has_role (AGENT ROLE and is_realized_in DNA CROSSLINKING) | removed has_role ANGIOGENESIS INHIBITOR; removed has_role ANTINEOPLASTIC ANTIBIOTIC; has_role some ANTINEOPLASTIC ALKYLATING AGENT; removed has_role ANTINEOPLASTIC ANTIBIOTIC |
| 147 | NPO_434 | THALIDOMIDE | | | has_function (THERAPEUTIC FUNCTION and is_realized_in ANGIOGENESIS INHIBITION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and (is_realized_in ANTINEOPLASTIC ACTIVITY)) | |
| 148 | NPO_737 | ANTINEOPLASTIC ANTIBIOTIC | | | has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH)) | |
| 149 | NPO_487 | ANTINEOPLASTIC METABOLITE | | | has_role (ANTIMETABOLITE ROLE and (is_realized_in NEGATIVE REGULATION OF DNA REPLICATION)) | removed inhibits DNA replication |
| 150 | NPO_939 | DNA BINDING AGENT | | | has_function (BINDING FUNCTION and (is_realized_in DNA BINDING)); has_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF DNA REPLICATION)) | removed inhibits DNA replication |