| No. | Code | Name | CLASS-LEVEL ANNOTATION | CLASS-LEVEL ASSERTION |
|---|
| new class-level annotation | changes to class-level annotation from previous version (2009-09-28) | new class-level assertion | changes to class-level assertion from previous version (2009-09-28) |
| 151 | NPO_130 | SELECTIVE ESTROGEN RECEPTOR MODULATOR | | | has_function (BINDING FUNCTION and (is_realized_in ESTROGEN RECEPTOR BINDING)) | |
| 152 | NPO_620 | DNA CROSSLINKING AGENT | | | has_role (AGENT ROLE and (is_realized_in DNA CROSSLINKING)); agent_in DNA CROSSLINKING | |
| 153 | NPO_235 | DNA ALKYLATING AGENT | | changed preferred name from ANTINEOPLASTIC ALKYLATING AGENT to DNA AKYLATING AGENT; added synonym ANTINEOPLASTIC ALKYLATING AGENT | has_function (ALKYLATING FUNCTION and (is_realized_in DNA ALKYLATION)) | |
| 154 | NPO_860 | PACLITAXEL | | | has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_function (BINDING FUNCTION and (is_realized_in BETA-TUBULIN BINDING)); has_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF MITOSIS)); has_role ANTICANCER DRUG ROLE | removed has_role TAXANE-POCKET BINDING AGENT; has_role ANTIMITOTIC AGENT |
| 155 | NPO_315 | TUBULIN BINDING AGENT | | | has_function (BINDING FUNCTION and (is_realized_in TUBULIN BINDING)) | |
| 156 | NPO_556 | TAXANE-POCKET BINDING AGENT | | | has_function (BINDING FUNCTION and (is_realized_in BETA-TUBULIN BINDING)) | |
| 157 | NPO_645 | TOPOTECAN | | | has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE I ACTIVTIY) | removed has_role TOPOISOMERASE-I INHIBITOR; inhibits TOPOISOMERASE TYPE I ACTIVTIY |
| 158 | NPO_597 | MITOXANTRONE | | | has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE II ACTIVTIY); has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH)) | removed has_role ANTINEOPLASTIC ANTIBIOTIC; removed has_role TOPOISOMERASE-II INHIBITOR; inhibits TOPOISOMERASE TYPE II ACTIVTIY |
| 159 | NPO_168 | ETOPOSIDE | | | has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE II ACTIVTIY) | removed has_role TOPOISOMERASE-II INHIBITOR;inhibits TOPOISOMERASE TYPE II ACTIVTIY |
| 160 | NPO_788 | DOXORUBICIN | | | has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH)); has_role (DNA INTERCALATOR ROLE and (is_realized_in DNA INTERCALATION)); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE II ACTIVTIY);has_role (REGULATOR ROLE and (is_realized_in REGULATION OF DNA-RNA TRANSCRIPTION REGULATOR) | removed has_role DNA INTERCALATING AGENT; has_role TOPOISOMERASE-II INHIBITOR; has_role ANTINEOPLASTIC ANTIBIOTIC; has_role DNA-RNA TRANSCRIPTION REGULATOR; inhibits TOPOISOMERASE TYPE II ACTIVTIY |
| 161 | NPO_817 | IDARUBICIN | | | has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH)); has_role (DNA INTERCALATOR ROLE and (is_realized_in DNA INTERCALATION)); regulates DNA-DEPENDENT TRANSCRIPTION | removed has_role DNA INTERCALATING AGENT; has_role TOPOISOMERASE-II INHIBITOR; has_role ANTINEOPLASTIC ANTIBIOTIC; has_role DNA-RNA TRANSCRIPTION REGULATOR; inhibits TOPOISOMERASE TYPE II ACTIVTIY |
| 162 | NPO_476 | DNA INTERCALATING AGENT | | | has_role (DNA INTERCALATOR ROLE and (is_realized_in DNA INTERCALATION)) | |
| 163 | NPO_365 | 5-FLUOROURACIL | | | has_role (ANTIMETABOLITE ROLE and (is_realized_in NEGATIVE REGULATION OF DNA REPLICATION)); inhibits THYMIDYLATE SYNTHASE ACTIVITY; has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF THYMIDYLATE SYNTHASE ACTIVITY)) | removed has_role ANTINEOPLASTIC ANTIMETABOLITE; has_role THYMIDYLATE SYNTHASE INHIBITOR |
| 164 | NPO_741 | METHOTREXATE | | | has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DIHYDROFOLATE REDUCTASE ACTIVITY)); has_role (ANTAGONIST ROLE and (is_realized_in some INHIBITION OF FOLIC ACID METABOLISM)) | removed has_role FOLATE ANTAGONIST; has_role DIHYDROFOLATE REDUCTASE INHIBITOR |
| 165 | NPO_123 | GEFINITIB | | | | removed has_role epidermal growth factor receptor tyrosine kinase inhibitor |
| 166 | NPO_608 | CISPLATIN | | | has_role (AGENT ROLE and is_realized_in DNA CROSSLINKING); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING) | removed has_role DNA CROSSLINKING AGENT |
| 167 | NPO_603 | CARBOPLATIN | | | has_role (AGENT ROLE and is_realized_in DNA CROSSLINKING); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING) | removed has_role DNA CROSSLINKING AGENT |
| 168 | NPO_749 | OXALIPLATIN | | | has_role (AGENT ROLE and is_realized_in DNA CROSSLINKING); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING) | removed has_role DNA CROSSLINKING AGENT |
| 169 | NPO_874 | MELPHALAN | | | has_function (ALKYLATING FUNCTION and is_realized_in DNA ALKYLATION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING) | removed has_role DNA ALKYLATING AGENT |
| 170 | NPO_352 | MITOMYCIN | | | has_function (ALKYLATING FUNCTION and is_realized_in DNA ALKYLATION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY);has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH));has_function (BINDING FUNCTION and is_realized_in DNA BINDING) | removed has_role DNA ALKYLATING AGENT |
| 171 | NPO_346 | CHLORAMBUCIL | | | has_function (ALKYLATING FUNCTION and is_realized_in DNA ALKYLATION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING) | removed has_role DNA ALKYLATING AGENT |
| 172 | NPO_890 | CYCLOPHOSPHAMIDE | | | has_function (ALKYLATING FUNCTION and is_realized_in DNA ALKYLATION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY; has_function (BINDING FUNCTION and is_realized_in DNA BINDING) | removed has_role DNA ALKYLATING AGENT |
| 173 | NPO_527 | CETUXIMAB | | | has_function (BINDING FUNCTION and (is_realized_in EPIDERMAL GROWTH FACTOR RECEPTOR BINDING)) | |
| 174 | NPO_460 | FOLATE ANTAGONIST | | added synonyms FOLIC ACID ANTAGONIST, FOLIC ACID INHIBITOR, FOLATE INHIBITOR | has_role (ANTAGONIST ROLE and (is_realized_in some INHIBITION OF FOLIC ACID METABOLISM)) | |
| 175 | NPO_778 | ANGIOGENIC INHIBITION | | changed preferred name from ANGIOGENIC INHIBITION to TUMOR ANGIOGENESIS INHIBITION | realizes INHIBITOR ROLE; inhibits TUMOR ANGIOGENESIS | removed inhibits ANGIOGENESIS |
| 176 | NPO_914 | INHIBITION OF CANCER CELL GROWTH | | | realizes INHIBITOR ROLE | |
| 177 | NPO_442 | ENZYME INHIBITOR DRUG | | | has_role (INHIBITOR ROLE and (is_realized_in ENZYME INHIBITION)) | removed inhibits ENZYME ACTIVITY |
| 178 | NPO_876 | DIHYDROFOLATE REDUCTASE INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DIHYDROFOLATE REDUCTASE ACTIVITY)) | |
| 179 | NPO_136 | ANTIMITOTIC AGENT | | | has_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF MITOSIS)) | removed inhibits CELL DIVISION; inhibits MITOSIS |
| 180 | NPO_124 | ANTI-ADHESION AGENT | | | has_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF CELL ADHESION)) | removed inhibits CELL ADHESION |
| 181 | NPO_594 | DNA SYNTHESIS INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF DNA REPLICATION)) | removed inhibits DNA replication |
| 182 | NPO_873 | ANTIMETASTATIC AGENT | | | has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF METASTASIS)) | removed inhibits METASTASIS |
| 183 | NPO_327 | DNA-RNA TRANSCRIPTION REGULATOR | | | has_role (REGULATOR ROLE and (is_realized_in REGULATION OF DNA-DEPENDENT TRANSCRIPTION) | removed regulates DNA-DEPENDENT TRANSCRIPTION |
| 184 | NPO_435 | THYMIDYLATE SYNTHASE INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF THYMIDYLATE SYNTHASE ACTIVITY)) | removed inhibits THYMIDYLATE SYNTHASE ACTIVITY |
| 185 | NPO_256 | TOPOISOMERASE INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE ACTIVITY)) | removed inhibits DNA TOPOISOMERASE ACTIVITY |
| 186 | NPO_784 | TOPOISOMERASE-II INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE II ACTIVITY)) | removed inhibits DNA TOPOISOMERASE TYPE II ACTIVITY |
| 187 | NPO_864 | TOPOISOMERASE-I INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE I ACTIVITY)) | removed inhibits DNA TOPOISOMERASE TYPE I ACTIVITY |
| 188 | NPO_436 | PROTEIN KINASE INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF PROTEIN KINASE ACTIVITY)) | removed inhibits PROTEIN KINASE ACTIVITY |
| 189 | NPO_567 | PROTEIN TYROSINE KINASE INHIBITOR | | | has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF PROTEIN TYROSINE KINASE ACTIVITY)) | removed inhibits PROTEIN TYROSINE KINASE ACTIVITY |
| 190 | NPO_639 | EMULSION | | | has_part EMULSIFIER; has_part (COMPOUND OR MOLECULE and (has_role EMULSFIFYING ROLE)) | |
| 191 | NPO_1487 | SAMPLE | | | | changed parent class from SUBSTANCE to MATERIAL FIAT PART |