Part 4

No.CodeNameCLASS-LEVEL ANNOTATIONCLASS-LEVEL ASSERTION
new class-level annotationchanges to class-level annotation from previous version (2009-09-28)new class-level assertionchanges to class-level assertion from previous version (2009-09-28)
151NPO_130SELECTIVE ESTROGEN RECEPTOR MODULATORhas_function (BINDING FUNCTION and (is_realized_in ESTROGEN RECEPTOR BINDING))
152NPO_620DNA CROSSLINKING AGENThas_role (AGENT ROLE and (is_realized_in DNA CROSSLINKING)); agent_in DNA CROSSLINKING
153NPO_235DNA ALKYLATING AGENTchanged preferred name from ANTINEOPLASTIC ALKYLATING AGENT to DNA AKYLATING AGENT; added synonym ANTINEOPLASTIC ALKYLATING AGENThas_function (ALKYLATING FUNCTION and (is_realized_in DNA ALKYLATION))
154NPO_860PACLITAXELhas_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_function (BINDING FUNCTION and (is_realized_in BETA-TUBULIN BINDING)); has_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF MITOSIS)); has_role ANTICANCER DRUG ROLEremoved has_role TAXANE-POCKET BINDING AGENT; has_role ANTIMITOTIC AGENT
155NPO_315TUBULIN BINDING AGENThas_function (BINDING FUNCTION and (is_realized_in TUBULIN BINDING))
156NPO_556TAXANE-POCKET BINDING AGENThas_function (BINDING FUNCTION and (is_realized_in BETA-TUBULIN BINDING))
157NPO_645TOPOTECANhas_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE I ACTIVTIY)removed has_role TOPOISOMERASE-I INHIBITOR; inhibits TOPOISOMERASE TYPE I ACTIVTIY
158NPO_597MITOXANTRONEhas_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE II ACTIVTIY); has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH))removed has_role ANTINEOPLASTIC ANTIBIOTIC; removed has_role TOPOISOMERASE-II INHIBITOR; inhibits TOPOISOMERASE TYPE II ACTIVTIY
159NPO_168ETOPOSIDEhas_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE II ACTIVTIY)removed has_role TOPOISOMERASE-II INHIBITOR;inhibits TOPOISOMERASE TYPE II ACTIVTIY
160NPO_788DOXORUBICINhas_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH)); has_role (DNA INTERCALATOR ROLE and (is_realized_in DNA INTERCALATION)); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE II ACTIVTIY);has_role (REGULATOR ROLE and (is_realized_in REGULATION OF DNA-RNA TRANSCRIPTION REGULATOR)removed has_role DNA INTERCALATING AGENT; has_role TOPOISOMERASE-II INHIBITOR; has_role ANTINEOPLASTIC ANTIBIOTIC; has_role DNA-RNA TRANSCRIPTION REGULATOR; inhibits TOPOISOMERASE TYPE II ACTIVTIY
161NPO_817IDARUBICINhas_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH)); has_role (DNA INTERCALATOR ROLE and (is_realized_in DNA INTERCALATION)); regulates DNA-DEPENDENT TRANSCRIPTIONremoved has_role DNA INTERCALATING AGENT; has_role TOPOISOMERASE-II INHIBITOR; has_role ANTINEOPLASTIC ANTIBIOTIC; has_role DNA-RNA TRANSCRIPTION REGULATOR; inhibits TOPOISOMERASE TYPE II ACTIVTIY
162NPO_476DNA INTERCALATING AGENThas_role (DNA INTERCALATOR ROLE and (is_realized_in DNA INTERCALATION))
163NPO_3655-FLUOROURACILhas_role (ANTIMETABOLITE ROLE and (is_realized_in NEGATIVE REGULATION OF DNA REPLICATION)); inhibits THYMIDYLATE SYNTHASE ACTIVITY; has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF THYMIDYLATE SYNTHASE ACTIVITY))removed has_role ANTINEOPLASTIC ANTIMETABOLITE; has_role THYMIDYLATE SYNTHASE INHIBITOR
164NPO_741METHOTREXATEhas_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY); has_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DIHYDROFOLATE REDUCTASE ACTIVITY)); has_role (ANTAGONIST ROLE and (is_realized_in some INHIBITION OF FOLIC ACID METABOLISM))removed has_role FOLATE ANTAGONIST; has_role DIHYDROFOLATE REDUCTASE INHIBITOR
165NPO_123GEFINITIBremoved has_role epidermal growth factor receptor tyrosine kinase inhibitor
166NPO_608CISPLATINhas_role (AGENT ROLE and is_realized_in DNA CROSSLINKING); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING)removed has_role DNA CROSSLINKING AGENT
167NPO_603CARBOPLATINhas_role (AGENT ROLE and is_realized_in DNA CROSSLINKING); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING)removed has_role DNA CROSSLINKING AGENT
168NPO_749OXALIPLATINhas_role (AGENT ROLE and is_realized_in DNA CROSSLINKING); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING)removed has_role DNA CROSSLINKING AGENT
169NPO_874MELPHALANhas_function (ALKYLATING FUNCTION and is_realized_in DNA ALKYLATION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING)removed has_role DNA ALKYLATING AGENT
170NPO_352MITOMYCINhas_function (ALKYLATING FUNCTION and is_realized_in DNA ALKYLATION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY);has_role (ANTIBIOTIC ROLE and (is_realized_in INHIBITION OF CANCER CELL GROWTH));has_function (BINDING FUNCTION and is_realized_in DNA BINDING)removed has_role DNA ALKYLATING AGENT
171NPO_346CHLORAMBUCILhas_function (ALKYLATING FUNCTION and is_realized_in DNA ALKYLATION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY;has_function (BINDING FUNCTION and is_realized_in DNA BINDING)removed has_role DNA ALKYLATING AGENT
172NPO_890CYCLOPHOSPHAMIDEhas_function (ALKYLATING FUNCTION and is_realized_in DNA ALKYLATION); has_role ANTICANCER DRUG ROLE; has_function (THERAPEUTIC FUNCTION and realized_as ANTINEOPLASTIC ACTIVITY; has_function (BINDING FUNCTION and is_realized_in DNA BINDING)removed has_role DNA ALKYLATING AGENT
173NPO_527CETUXIMABhas_function (BINDING FUNCTION and (is_realized_in EPIDERMAL GROWTH FACTOR RECEPTOR BINDING))
174NPO_460FOLATE ANTAGONISTadded synonyms FOLIC ACID ANTAGONIST, FOLIC ACID INHIBITOR, FOLATE INHIBITORhas_role (ANTAGONIST ROLE and (is_realized_in some INHIBITION OF FOLIC ACID METABOLISM))
175NPO_778ANGIOGENIC INHIBITIONchanged preferred name from ANGIOGENIC INHIBITION to TUMOR ANGIOGENESIS INHIBITIONrealizes INHIBITOR ROLE; inhibits TUMOR ANGIOGENESISremoved inhibits ANGIOGENESIS
176NPO_914INHIBITION OF CANCER CELL GROWTHrealizes INHIBITOR ROLE
177NPO_442ENZYME INHIBITOR DRUGhas_role (INHIBITOR ROLE and (is_realized_in ENZYME INHIBITION))removed inhibits ENZYME ACTIVITY
178NPO_876DIHYDROFOLATE REDUCTASE INHIBITORhas_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DIHYDROFOLATE REDUCTASE ACTIVITY))
179NPO_136ANTIMITOTIC AGENThas_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF MITOSIS))removed inhibits CELL DIVISION; inhibits MITOSIS
180NPO_124ANTI-ADHESION AGENThas_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF CELL ADHESION))removed inhibits CELL ADHESION
181NPO_594DNA SYNTHESIS INHIBITORhas_role (INHIBITOR ROLE and (is_realized_in NEGATIVE REGULATION OF DNA REPLICATION))removed inhibits DNA replication
182NPO_873ANTIMETASTATIC AGENThas_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF METASTASIS))removed inhibits METASTASIS
183NPO_327DNA-RNA TRANSCRIPTION REGULATORhas_role (REGULATOR ROLE and (is_realized_in REGULATION OF DNA-DEPENDENT TRANSCRIPTION)removed regulates DNA-DEPENDENT TRANSCRIPTION
184NPO_435THYMIDYLATE SYNTHASE INHIBITORhas_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF THYMIDYLATE SYNTHASE ACTIVITY))removed inhibits THYMIDYLATE SYNTHASE ACTIVITY
185NPO_256TOPOISOMERASE INHIBITORhas_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE ACTIVITY))removed inhibits DNA TOPOISOMERASE ACTIVITY
186NPO_784TOPOISOMERASE-II INHIBITORhas_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE II ACTIVITY))removed inhibits DNA TOPOISOMERASE TYPE II ACTIVITY
187NPO_864TOPOISOMERASE-I INHIBITORhas_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF DNA TOPOISOMERASE TYPE I ACTIVITY))removed inhibits DNA TOPOISOMERASE TYPE I ACTIVITY
188NPO_436PROTEIN KINASE INHIBITORhas_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF PROTEIN KINASE ACTIVITY))removed inhibits PROTEIN KINASE ACTIVITY
189NPO_567PROTEIN TYROSINE KINASE INHIBITORhas_role (INHIBITOR ROLE and (is_realized_in INHIBITION OF PROTEIN TYROSINE KINASE ACTIVITY))removed inhibits PROTEIN TYROSINE KINASE ACTIVITY
190NPO_639EMULSIONhas_part EMULSIFIER; has_part (COMPOUND OR MOLECULE and (has_role EMULSFIFYING ROLE))
191NPO_1487SAMPLEchanged parent class from SUBSTANCE to MATERIAL FIAT PART
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